Includes bibliographical references and index
|Statement||edited by Neil M. Nathanson and T. Kendall Harden|
|Series||Society of General Physiologists series -- v. 45, Society of General Physiologists series -- v. 45|
|Contributions||Harden, T. Kendall, Nathanson, Neil M|
|The Physical Object|
|Pagination||vi, 210 p. :|
|Number of Pages||210|
|LC Control Number||90-81669|
Signal Transduction, 2e, is a thorough, well-illustrated study in cellular signaling processes. Beginning with the basics, this book shows how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and further instructs how these inputs are integrated. Both the number and functions of G proteins have grown dramatically and the Society of General Physiologists dedicated their 43rd annual symposium to the topic of G proteins and signal transduction. This book contains the abstracts and proceedings of that symposium. Purchase Signal Transduction - 3rd Edition. Print Book & E-Book. ISBN , COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus.
In a new chapter, an introduction to signal transduction, the book provides a concise overview of receptor mechanisms, from receptor –ligand interactions to post-translational modifications Author: Ijsbrand Kramer. The roles of G-protein alpha-subunits in these processes and for the specificity of signal transduction are largely established; the beta- and gamma-subunits are essential for receptor-induced G. Signal Transduction by G proteins • Discovery and Structure of Heterotrimeric G proteins • Signaling pathways of G proteins to block the normal protein’s signal The mutant exerts the same effect as the normal protein would, if it were activated in the cell. Reverse genetics: small GTPases as examples. The three main classes of intracellular signaling proteins are: G proteins (GTPase switch proteins) - These proteins change between an active conformation when bound to GTP, and an inactive conformation when bound to GDP. IN the absence of a signal they are bound to GDP. Signal results in the release of GDP and the binding of abundant GTP.
ISBN: OCLC Number: Description: xii, pages: illustrations ; 24 cm: Contents: Guanine nucleotide-binding proteins in health and disease: an overview / G. Milligan --Mutations within the gene encoding the stimulatory G-protein of adenylyl cyclase as the basis for Albright Hereditary Osteodystrophy / A. Miric and M.A. Levine --GTP-binding proteins and. G Proteins is an introduction to one class of systems used for signal transduction at the cell surface, with emphasis on its utilization of a heterotrimeric GTP-binding protein (G protein) to mediate the transfer of information across the plasma membrane, from receptor to Edition: 2. Another field covered, one rarely highlighted in signal transduction books, is that of signaling platforms, which has been emerging as a significant research area relevant to cellular metabolism, cell proliferation, differentiation, apoptosis, neurodegenerative diseases, and cancer. ﬁeld of signal transduction, who established principles of protein–protein interactions that have profoundly inﬂuenced our understanding of signal transduction. His enduring legacy will be the discovery that the Src homology 2 (SH2) domain of one protein can selectivelyFile Size: KB.